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SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
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2018 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, article id annrheumdis-2017-212794Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVES: risk allele rs7574865[T] affects the function of immune cells in SLE.

METHODS: risk allele carriership. Janus kinase inhibitors (JAKi) selective for TYK2 (TYK2i) or JAK2 (JAK2i) were evaluated for inhibition of IL-12 or IFN-γ-induced activation of SLE PBMCs.

RESULTS: risk patients, respectively.

CONCLUSIONS: risk allele rs7574865[T] display an augmented response to IL-12 and IFN-α. This subset of patients may benefit from JAKi treatment.

Place, publisher, year, edition, pages
2018. article id annrheumdis-2017-212794
Keywords [en]
IL-12, JAK inhibitors, STAT4, interferon, systemic lupus erythematosus
National Category
Rheumatology and Autoimmunity
Research subject
Medical Genetics; Medical Science
Identifiers
URN: urn:nbn:se:uu:diva-343241DOI: 10.1136/annrheumdis-2017-212794PubMedID: 29475858OAI: oai:DiVA.org:uu-343241DiVA, id: diva2:1185796
Available from: 2018-02-26 Created: 2018-02-26 Last updated: 2018-02-26

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