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G-CSF mobilized peripheral blood stem cell collection for allogeneic transplantation in healthy donors: Analysis of factors affecting yield
Karolinska Univ Hosp, Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ Hosp, Hematol Ctr Karolinska, M54, SE-14186 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology. Karolinska Univ Hosp, Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ Hosp, Hematol Ctr Karolinska, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ Hosp, Hematol Ctr Karolinska, M54, SE-14186 Stockholm, Sweden..
Poznan Univ Med Sci, Dept Hematol & Bone Marrow Transplantat, Poznan, Poland..
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2017 (English)In: Journal of clinical apheresis, ISSN 0733-2459, E-ISSN 1098-1101, Vol. 32, no 6, p. 384-391Article in journal (Refereed) Published
Abstract [en]

Mobilized PBSC are the main source for allogeneic HSCT. We aimed to evaluate factors that affect CD34+ cell yield including the donor's age, gender, BSA, processed blood volume and the method of G-CSF dose calculation. Data from 170 healthy donors were analyzed. The concentration of CD34+ cells in the peripheral blood (PB) and the processed volume of blood were significantly correlated to CD34+ cells yield (P<.00005 and P<.001, respectively). The G-CSF dose per m(2) was significantly correlated to the concentration of CD34+ cells in the PB (P=.0003) and in the product (P=.01). Smaller BSA and less processed volume were found among female donors, who were given lesser G-CSF dose perm(2), and showed lower yield compared to men. However, multivariate analysis of the yield showed that only the concentration of CD34+ cells in the PB and the processed volume remained independent significant.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 32, no 6, p. 384-391
Keywords [en]
collection, healthy donors, G-CSF, mobilization, PBSC donation
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-342662DOI: 10.1002/jca.21524ISI: 000415743800002PubMedID: 28101890OAI: oai:DiVA.org:uu-342662DiVA, id: diva2:1186180
Available from: 2018-02-27 Created: 2018-02-27 Last updated: 2018-02-27Bibliographically approved

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