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Small airways dysfunction: the link between allergic rhinitis and allergic asthma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology. (Clinical Physiology)
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2018 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 51, no 2, article id 1701749Article in journal (Refereed) Published
Abstract [en]

Abnormal airway reactivity and overproduction of nitric oxide (NO) occurring in smallairways have been found in asthma. If the“one airway, one disease”concept is consistent, suchdysfunctions should also be detected in the peripheral airways of patients suffering from allergicrhinitis.We investigated whether peripheral airway reactivity and NO overproduction could bedocumented in distal airways in patients with allergic rhinitis. Exhaled NO fraction (FeNO)andtheslope (S) of phase III of the single-breath washout test (SBWT) of helium (He) and sulfurhexafluoride (SF6)weremeasuredin31patientswithallergicasthma,23allergicrhinitispatientsand 24 controls, before and after sputum induction. SBWT is sensitive to airway calibre changeoccurring in the lung periphery.TheFeNOdecrease was more significant in asthma and rhinitis than in controls (−55.1% and−50.0%,respectively,versus−40.8%) (p=0.007 and p=0.029, respectively). SSF6and SHeincreased in all groups.Change in SHe(ΔSHe)>ΔSSF6was observed in rhinitis (p=0.004) and asthma (p<0.001), whereasΔSSF6=ΔSHein controls (p=0.431).This study provides evidence of peripheral airway dysfunction in patients with allergic rhinitis quitesimilar to that described in asthma. Furthermore, a large proportion of the increased NO productionreported in allergic rhinitis appears to originate in the peripheral airways.

Place, publisher, year, edition, pages
2018. Vol. 51, no 2, article id 1701749
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Respiratory Medicine and Allergy
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URN: urn:nbn:se:uu:diva-343516DOI: 10.1183/13993003.01749-2017ISI: 000429419700006PubMedID: 29467201OAI: oai:DiVA.org:uu-343516DiVA, id: diva2:1186261
Available from: 2018-02-27 Created: 2018-02-27 Last updated: 2018-07-13Bibliographically approved

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