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Histopathological classification of non-functioning pituitary neuroendocrine tumors
Univ Belgrade, Inst Pathol, Sch Med, Belgrade, Serbia.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology and mineral metabolism.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.ORCID iD: 0000-0001-7376-7331
2018 (English)In: Pituitary, ISSN 1386-341X, E-ISSN 1573-7403, Vol. 21, no 2, p. 119-129Article, review/survey (Refereed) Published
Abstract [en]

Non-functioning pituitary neuroendocrine tumors do not cause endocrine symptoms related to hypersecretion of adenohypophyseal hormones and are clinically characterized by symptoms due to growing sellar tumor mass. Histopathological classification of this tumor group has always been challenging due to their heterogeneity, limited knowledge on their biology, and diverse methodological problems. We have searched PubMed database for data related to the histopathological classification of non-functioning pituitary tumors and methods for its application. Principles of the classification and grading presented in the recently released 4th edition of the World Health Organization classification of endocrine tumors have been summarized. Based on the expression of anterior pituitary hormones and pituitary specific transcription factors, gonadotroph tumors dominate within the group of clinically non-functioning tumors, followed by corticotroph type; however, other less common types of the non-functioning tumors can be identified. Assessment of tumor cell proliferation is important to identify "high-risk adenomas." A few subtypes of non-functioning tumors belong to the category of potentially aggressive tumors, independent of the cell proliferation rate. Here, we present up to date criteria for the classification of clinically non-functioning pituitary tumors, offer a diagnostic approach for the routine clinical use, and emphasize a need for inclusion of prognostic and predictive markers in the classification.

Place, publisher, year, edition, pages
2018. Vol. 21, no 2, p. 119-129
Keywords [en]
Immunohistochemistry, Non-functioning pituitary neuroendocrine tumor, Pituitary adenoma, Transcription factors
National Category
Cancer and Oncology Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-343603DOI: 10.1007/s11102-017-0855-1ISI: 000427498400003PubMedID: 29275530OAI: oai:DiVA.org:uu-343603DiVA, id: diva2:1186370
Note

Special Issue: SI

Available from: 2018-02-28 Created: 2018-02-28 Last updated: 2018-07-19Bibliographically approved

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Engström, Britt EdénCasar-Borota, Olivera

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