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Bone markers in polycystic ovary syndrome: A multicentre study
Oulu Univ Hosp, Dept Obstet & Gynaecol, PEDEGO Res Unit, Med Res Ctr, Oulu, Finland.;Univ Oulu, Oulu, Finland..
Oulu Univ Hosp, Dept Obstet & Gynaecol, PEDEGO Res Unit, Med Res Ctr, Oulu, Finland.;Univ Oulu, Oulu, Finland..
Oulu Univ Hosp, Dept Obstet & Gynaecol, PEDEGO Res Unit, Med Res Ctr, Oulu, Finland.;Univ Oulu, Oulu, Finland..
Oulu Univ Hosp, Dept Obstet & Gynaecol, PEDEGO Res Unit, Med Res Ctr, Oulu, Finland.;Univ Oulu, Oulu, Finland..
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2017 (English)In: Clinical Endocrinology, ISSN 0300-0664, E-ISSN 1365-2265, Vol. 87, no 6, p. 673-679Article in journal (Refereed) Published
Abstract [en]

Objective: Hyperandrogenism, hyperinsulinaemia and obesity, known characteristics of polycystic ovary syndrome (PCOS), may influence bone mineral density and biochemical markers of bone turnover (BTMs) can provide a noninvasive assessment of bone turnover. To this end, the serum concentrations of BTMs and 25-hydroxyvitamin D (25OHD) were analysed in women with PCOS, and their possible associations with metabolic parameters of PCOS were determined.

Subjects and methods: Bone formation markers procollagen type I amino-terminal propeptide (PINP) and osteocalcin (OC), and bone resorption marker carboxy-terminal cross-linking telopeptide of type I collagen (CTX), along with 25OHD, were measured in 298 women with PCOS and 194 healthy controls.

Results: Serum levels of PINP (47.020.2 vs 58.1 +/- 28.6g/L, P<.001) and OC (18.2 +/- 7.5 vs 20.6 +/- 9.8g/L, P<.001) were decreased in women with PCOS compared with controls, whereas no significant differences were found in CTX and 25OHD levels. Age-stratified analyses suggested that PINP (50.5 +/- 21.7 vs 68.2 +/- 26.6g/L, P<.001) and OC levels (20.4 +/- 7.6 vs 25.5 +/- 9.6g/L, P<.001) were decreased only in the younger age group (30years) women with PCOS compared with controls. The formation markers and resorption marker decreased with age in both study groups.

Conclusions: Bone formation markers were decreased in younger women with PCOS when compared with healthy women, which may affect bone mass in these women.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 87, no 6, p. 673-679
Keywords [en]
biochemical markers of bone turnover, carboxy-terminal cross-linking telopeptide of type I collagen, osteocalcin, polycystic ovary syndrome, procollagen type I amino-terminal propeptide
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-343559DOI: 10.1111/cen.13456ISI: 000415895800006PubMedID: 28845895OAI: oai:DiVA.org:uu-343559DiVA, id: diva2:1187219
Available from: 2018-03-02 Created: 2018-03-02 Last updated: 2018-03-02Bibliographically approved

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Sundström Poromaa, Inger

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