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Harnessing transcription for bioproduction in cyanobacteria
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.ORCID iD: 0000-0001-6993-8476
Univ Copenhagen, Dept Plant & Environm Sci, Copenhagen Plant Sci Ctr, Frederiksberg C, Denmark..
Univ Turku, Dept Biochem, Mol Plant Biol, FI-20014 Turku, Finland..
2018 (English)In: Physiologia Plantarum: An International Journal for Plant Biology, ISSN 0031-9317, E-ISSN 1399-3054, Vol. 162, no 2, p. 148-155Article in journal (Refereed) Published
Abstract [en]

Sustainable production of biofuels and other valuable compounds is one of our future challenges. One tempting possibility is to use photosynthetic cyanobacteria as production factories. Currently, tools for genetic engineering of cyanobacteria are not good enough to exploit the full potential of cyanobacteria. A wide variety of expression systems will be required to adjust both the expression of heterologous enzyme(s) and metabolic routes to the best possible balance, allowing the optimal production of a particular substance. In bacteria, transcription, especially the initiation of transcription, has a central role in adjusting gene expression and thus also metabolic fluxes of cells according to environmental cues. Here we summarize the recent progress in developing tools for efficient cyanofactories, focusing especially on transcriptional regulation.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 162, no 2, p. 148-155
National Category
Industrial Biotechnology
Identifiers
URN: urn:nbn:se:uu:diva-343779DOI: 10.1111/ppl.12606ISI: 000423541700002PubMedID: 28762505OAI: oai:DiVA.org:uu-343779DiVA, id: diva2:1187887
Funder
Swedish Energy AgencyKnut and Alice Wallenberg FoundationAvailable from: 2018-03-06 Created: 2018-03-06 Last updated: 2018-03-06Bibliographically approved

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Stensjö, Karin

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