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Circulating Serum 25-Hydroxyvitamin D Levels and Bone Mineral Density: Mendelian Randomization Study.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
2018 (English)In: Journal of Bone and Mineral Research, ISSN 0884-0431, E-ISSN 1523-4681Article in journal (Refereed) Epub ahead of print
Abstract [en]

change in BMD -0.03; 95% CI -0.05 to -0.01; p = 0.02). This study does not support a causal association between long-term elevated S-25OHD concentrations and higher BMD in generally healthy populations. These results suggest that more emphasis should be placed on the development of evidence-based cut-off points for vitamin D inadequacy rather than a general recommendation to increase S-25OHD. © 2018 American Society for Bone and Mineral Research.

Place, publisher, year, edition, pages
2018.
Keywords [en]
BONE MINERAL DENSITY, MENDELIAN RANDOMIZATION, OSTEOPOROSIS, SINGLE-NUCLEOTIDE POLYMORPHISMS, VITAMIN D
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-344294DOI: 10.1002/jbmr.3389PubMedID: 29338102OAI: oai:DiVA.org:uu-344294DiVA, id: diva2:1187971
Available from: 2018-03-06 Created: 2018-03-06 Last updated: 2018-03-06

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