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New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia
Inst Chem Biol & Fundamental Med SB RAS, Novosibirsk, Russia..
Inst Systemat & Ecol Anim SB RAS, Novosibirsk, Russia..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Inst Chem Biol & Fundamental Med SB RAS, Novosibirsk, Russia.;Natl Inst Hlth Dev, Tallinn, Estonia.
Inst Chem Biol & Fundamental Med SB RAS, Novosibirsk, Russia..
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2017 (English)In: Infection, Genetics and Evolution, ISSN 1567-1348, E-ISSN 1567-7257, Vol. 56, p. 36-43Article in journal (Refereed) Published
Abstract [en]

Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is a causative agent of a severe neurological disease. There are three main TBEV subtypes: the European (TBEV-Eu), Far Eastern (TBEV-FE), and Siberian (TBEV-Sib). Currently, three lineages within TBEV-Sib have been recorded. In this study, the genetic and biological characteristics of a new original strain, TBEV-2871, isolated in the Novosibirsk province of Western Siberia, Russia were investigated. The strain has low neuroinvasiveness in mice. Phylogenetic analysis demonstrated that TBEV-2871 belongs to TBEV-Sib, but does not cluster with any of the TBEV-Sib lineages. The TBEV-2871 strain has 88-89% nucleotide sequence identity with the other TBEV-Sib strains, 84-86% nucleotide sequence identity with the TBEV-FE and TBEV-Eu subtypes and is genetically close to the subtype division border. The TBEV-2871 polyprotein sequence includes 43 unique amino acid substitutions, 30 of which are recorded at positions that are conserved among all TBEV subtypes. Strain TBEV-2871 and two similar but not identical isolates found in Kemerovo province, Western Siberia are separated into a new lineage tentatively named Obskaya after the name of Ob riber, in the vicinity of which the TBEV-2871 was first found. A molecular evolution investigation demonstrated that within TBEV-Sib, the Obskaya lineage likely separated 1535 years ago, which is even earlier than the Baltic lineage.

Place, publisher, year, edition, pages
2017. Vol. 56, p. 36-43
Keywords [en]
Tick-borne encephalitis virus, Western Siberia, Siberian subtype, Lineages
National Category
Microbiology in the medical area Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-345073DOI: 10.1016/j.meegid.2017.10.020ISI: 000417474500005PubMedID: 29069610OAI: oai:DiVA.org:uu-345073DiVA, id: diva2:1188535
Available from: 2018-03-07 Created: 2018-03-07 Last updated: 2018-03-07Bibliographically approved

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