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Analytical techniques for the characterization of Antibody Drug Conjugates: Challenges and prospects
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.ORCID iD: 0000-0002-4597-041x
2017 (English)In: European journal of mass spectrometry, ISSN 1469-0667, E-ISSN 1751-6838, Vol. 23, no 6, p. 417-426Article in journal (Refereed) Published
Abstract [en]

Antibody drug conjugates are increasingly being researched for the treatment of cancer. Accurate and reliable characterization of ADCs is inevitable for their development as potential therapeutic agent. Different analytical techniques have been used in order to decipher heterogeneous nature of antibody drug conjugates, enabling successful characterization. This review will summarize specially three major analytical tools i.e. UV-Vis spectroscopy, liquid chromatography, and mass spectrometry used in characterization of antibody drug conjugates. In this review, major challenges during analysis due to the inherent features of analytical techniques and antibody drug conjugates are summarized along with the modifications intended to address each challenge.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD , 2017. Vol. 23, no 6, p. 417-426
Keywords [en]
Antibody drug conjugate, hydrophobic interaction chromatography, mass spectrometry, reversed phase liquid chromatography, size exclusion chromatography, UV-Vis spectroscopy
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-345121DOI: 10.1177/1469066717733919ISI: 000423263100014PubMedID: 29183195OAI: oai:DiVA.org:uu-345121DiVA, id: diva2:1189552
Funder
Swedish Research Council, 2015-4870Available from: 2018-03-12 Created: 2018-03-12 Last updated: 2018-03-12Bibliographically approved

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