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Potentially Immunogenic Contaminants in Wood-Based and Bacterial Nanocellulose: Assessment of Endotoxin and (1,3)-β-d-Glucan Levels
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. Jiangsu Univ, Sch Environm & Safety Engn, Biofuels Inst, Zhenjiang.ORCID iD: 0000-0001-5393-3187
Univ Nat Resources & Appl Life Sci BOKU, Dept Chem, Vienna.
Univ Nat Resources & Appl Life Sci BOKU, Dept Chem, Vienna; Åbo Akad Univ, Lab Wood & Paper Chem, Johan Gadolin Proc Chem Ctr, Turku.
Åbo Akad Univ, Lab Wood & Paper Chem, Johan Gadolin Proc Chem Ctr, Turku.
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2018 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 19, no 1, p. 150-157Article in journal (Refereed) Published
Abstract [en]

Knowledge gaps in the biosafety data of the nanocellulose (NC) for biomedical use through various routes of administration call for closer look at health and exposure evaluation. This work evaluated the potentially immunogenic contaminants levels, for example, endotoxin and (1,3)-β-d-glucan, in four representative NCs, that is, wood-based NCs and bacterial cellulose (BC). The hot-water extracts were analyzed with ELISA assays, HPSEC-MALLS, GC, and NMR analysis. Varying levels of endotoxin and (1,3)-β-d-glucan contaminats were found in these widely used NCs. Although the β-(1,3)-d-glucan was not detected from the NMR spectra due to the small extract samples amount (2–7 mg), the anomerics and highly diastereotopic 6-CH2 signals may suggest the presence of β-(1,4)-linkages with β-(1,6) branching in the polysaccharides of NCs’ hot-water extracts, which were otherwise not detectable in the enzymatic assay. In all, the article highlights the importance of monitoring various water-soluble potentially immunogenic contaminants in NC for biomedical use.

Place, publisher, year, edition, pages
2018. Vol. 19, no 1, p. 150-157
National Category
Analytical Chemistry Biochemistry and Molecular Biology Polymer Chemistry Organic Chemistry Engineering and Technology
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URN: urn:nbn:se:uu:diva-343880DOI: 10.1021/acs.biomac.7b01334ISI: 000419998600015PubMedID: 29182312OAI: oai:DiVA.org:uu-343880DiVA, id: diva2:1190937
Funder
Knut and Alice Wallenberg FoundationStiftelsen Olle Engkvist ByggmästareAvailable from: 2018-03-16 Created: 2018-03-16 Last updated: 2018-03-28Bibliographically approved

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Liu, JunMihranyan, Albert

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