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Binary particle separation in droplet microfluidics using acoustophoresis
Lund Univ, Dept Biomed Engn, Lund, Sweden..
Lund Univ, Dept Biomed Engn, Lund, Sweden..
Lund Univ, Dept Biomed Engn, Lund, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. Uppsala University, Science for Life Laboratory, SciLifeLab. Lund Univ, Dept Biomed Engn, Lund, Sweden.ORCID iD: 0000-0002-1264-1337
2018 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 112, no 6, article id 063701Article in journal (Refereed) Published
Abstract [en]

We show a method for separation of two particle species with different acoustic contrasts originally encapsulated in the same droplet in a continuous two-phase system. This was realized by using bulk acoustic standing waves in a 380 mu m wide silicon-glass microfluidic channel. Polystyrene particles (positive acoustic contrast particles) and in-house synthesized polydimethylsiloxane (PDMS) particles (negative acoustic contrast particles) were encapsulated inside water-in-oil droplets either individually or in a mixture. At acoustic actuation of the system at the fundamental resonance frequency, the polystyrene particles were moved to the center of the droplet (pressure node), while the PDMS particles were moved to the sides of the droplet (pressure anti-nodes). The acoustic particle manipulation step was combined in series with a trifurcation droplet splitter, and as the original droplet passed through the splitter and was divided into three daughter droplets, the polystyrene particles were directed into the center daughter droplet, while the PDMS particles were directed into the two side daughter droplets. The presented method expands the droplet microfluidics tool-box and offers new possibilities to perform binary particle separation in droplet microfluidic systems.

Place, publisher, year, edition, pages
2018. Vol. 112, no 6, article id 063701
National Category
Physical Sciences Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-347079DOI: 10.1063/1.5020356ISI: 000424703200040OAI: oai:DiVA.org:uu-347079DiVA, id: diva2:1193100
Funder
Swedish Research CouncilThe Crafoord FoundationStiftelsen Olle Engkvist ByggmästareAvailable from: 2018-03-26 Created: 2018-03-26 Last updated: 2018-04-04Bibliographically approved

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The full text will be freely available from 2019-03-27 14:49
Available from 2019-03-27 14:49

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Tenje, Maria

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