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Sulfonimidamides in Medicinal and Agricultural Chemistry
University of KwaZulu Natal, Durban, South Africa.ORCID iD: 0000-0002-8344-2415
University of KwaZulu Natal, Durban, South Africa.
University of KwaZulu Natal, Durban, South Africa.
University of KwaZulu Natal, Durban, South Africa.
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2017 (English)In: Angewandte Chemie International Edition, Vol. 56, p. 4100-4109Article in journal, Editorial material (Refereed) Published
Abstract [en]

The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.

Place, publisher, year, edition, pages
2017. Vol. 56, p. 4100-4109
Keywords [en]
Sulfonimidamide
National Category
Medicinal Chemistry
Research subject
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-347155DOI: 10.1002/anie.201610456OAI: oai:DiVA.org:uu-347155DiVA, id: diva2:1193408
Available from: 2018-03-26 Created: 2018-03-26 Last updated: 2018-04-18Bibliographically approved

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Chinthakindi, Praveen Kumar
Medicinal Chemistry

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