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Indoor bacteria and asthma in adults: a multicentre case-control study within ECRHS II
Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.;Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland..
Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.;Univ Eastern Finland, Dept Environm & Biol Sci, Kuopio, Finland..
Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland..
ISGlobal, Barcelona Inst Global Hlth, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBER Epidemiol Salud Publ, CIBERESP, Madrid, Spain..
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2018 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 51, no 2, article id 1701241Article in journal (Refereed) Published
Abstract [en]

Both protective and adverse effects of indoor microbial exposure on asthma have been reported, but mostly in children. To date, no study in adults has used non-targeted methods for detection of indoor bacteria followed by quantitative confirmation. A cross-sectional study of 198 asthmatic and 199 controls was conducted within the European Community Respiratory Health Survey (ECRHS) II. DNA was extracted from mattress dust for bacterial analysis using denaturing gradient gel electrophoresis (DGGE). Selected bands were sequenced and associations with asthma confirmed with four quantitative PCR (qPCR) assays. 15 out of 37 bands detected with DGGE, which had at least a suggestive association (p<0.25) with asthma, were sequenced. Of the four targeted qPCRs, Clostridium cluster XI confirmed the protective association with asthma. The association was dose dependent (aOR 0.43 (95% CI 0.22-0.84) for the fourth versus first quartile, p for trend 0.009) and independent of other microbial markers. Few significant associations were observed for the three other qPCRs used. In this large international study, the level of Clostridium cluster XI was independently associated with a lower risk of prevalent asthma. Results suggest the importance of environmental bacteria also in adult asthma, but need to be confirmed in future studies.

Place, publisher, year, edition, pages
EUROPEAN RESPIRATORY SOC JOURNALS LTD , 2018. Vol. 51, no 2, article id 1701241
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Respiratory Medicine and Allergy
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URN: urn:nbn:se:uu:diva-346883DOI: 10.1183/13993003.01241-2017ISI: 000424396500007OAI: oai:DiVA.org:uu-346883DiVA, id: diva2:1193942
Available from: 2018-03-28 Created: 2018-03-28 Last updated: 2018-03-28Bibliographically approved

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Janson, Christer

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