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Nanoparticle-loaded hydrogels as a pathway for enzyme-triggered drug release in ophthalmic applications
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.ORCID iD: 0000-0001-7638-0925
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
2018 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 536, no 1, p. 73-81Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to develop nanoparticle loaded hydrogel based contact lenses that could be used for ocular drug delivery. Two potential contact lens platforms for controlled ophthalmic drug delivery were developed by incorporating chitosan-poly (acrylic acid) nanoparticles into polyvinyl alcohol (PVA) hydrogels and in-situ gelled nanoparticles and cellulose nanocrystals (CNC) in PVA lenses. The nanoparticles were shown to disintegrate in a physiological 0.2 mM concentration of lysozyme resulting from the hydrolysis of the chitosan chains by lysozyme. An extended release over a 28-h period was demonstrated once the nanoparticles had been integrated into the composite lenses, with nanoparticle-CNC PVA lenses showing even greater potential for extended release. The platform shows great promise in developing enzyme-triggered ocular drug delivery systems.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 536, no 1, p. 73-81
Keywords [en]
Cellulose nanocrystals, Chitosan, Fluorescence microscopy, Lysozyme, Polyacrylic acid, Polyvinyl alcohol
National Category
Pharmaceutical Sciences Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-346891DOI: 10.1016/j.ijpharm.2017.11.053ISI: 000424259100008PubMedID: 29180255OAI: oai:DiVA.org:uu-346891DiVA, id: diva2:1193944
Available from: 2018-03-28 Created: 2018-03-28 Last updated: 2018-03-28Bibliographically approved

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Tummala, Gopi KrishnaMihranyan, Albert

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