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Large-scale brain simulation and disorders of consciousness: Mapping technical and conceptual issues
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics. Science and Society Unit, Biogem Genetic Research Centre, Ariano Irpino (AV), Italy. (Neuroethics)ORCID iD: 0000-0002-3298-7829
Science for Life Laboratory, School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Neuroscience, Karolinska Institute, Solna, Sweden. (Neuroscience)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics.
2018 (English)In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 9, article id 585Article in journal (Refereed) Published
Abstract [en]

Modelling and simulations have gained a leading position in contemporary attempts to describe, explain, and quantitatively predict the human brain's operations. Computer models are highly sophisticated tools developed to achieve an integrated knowledge of the brain with the aim of overcoming the actual fragmentation resulting from different neuroscientific approaches. In this paper we investigate plausibility of simulation technologies for emulation of consciousness and the potential clinical impact of large-scale brain simulation on the assessment and care of disorders of consciousness (DOCs), e.g. Coma, Vegetative State/Unresponsive Wakefulness Syndrome, Minimally Conscious State.Notwithstanding their technical limitations, we suggest that simulation technologies may offer new solutions to old practical problems, particularly in clinical contexts. We take DOCs as an illustrative case, arguing that the simulation of neural correlates of consciousness is potentially useful for improving treatments of patients with DOCs.

Place, publisher, year, edition, pages
2018. Vol. 9, article id 585
Keywords [en]
Consciousness, Consciousness Disorders, brain modeling, Neuroethics, brain simulation
National Category
Computer Systems Ethics Philosophy Neurology Bioinformatics and Systems Biology
Research subject
Neuroscience; Philosophy
Identifiers
URN: urn:nbn:se:uu:diva-347782DOI: 10.3389/fpsyg.2018.00585ISI: 000430833800001PubMedID: 29740372OAI: oai:DiVA.org:uu-347782DiVA, id: diva2:1195844
Projects
The human brain project
Funder
EU, Horizon 2020, 720270Available from: 2018-04-06 Created: 2018-04-06 Last updated: 2018-06-26Bibliographically approved

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Farisco, MicheleEvers, Kathinka

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