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Maintaining and repeating tocolysis: A reflection on evidence
Univ Ghent, Dept Gynecol & Obstet, UZ Gent, Ghent, Belgium.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Obstetrics.
Tampere Univ Hosp, Dept Gynecol & Obstet, Tampere, Finland.
Kings Coll London, Div Womens Hlth, London, England.
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2017 (English)In: Seminars in Perinatology, ISSN 0146-0005, E-ISSN 1558-075X, Vol. 41, no 8, p. 468-476Article, review/survey (Refereed) Published
Abstract [en]

It is inherent to human logic that both doctors and patients want to suppress uterine contractions when a woman presents in threatened preterm labor. Tocolysis is widely applied in women with threatened preterm labor with a variety of drugs. According to literature, tocolysis is indicated to enable transfer to a tertiary center as well as to ensure the administration of corticosteroids for fetal maturation. There is international discrepancy in the content and the implementation of guidelines on preterm labor. Tocolysis is often maintained or repeated. Nevertheless, the benefit of prolonging pregnancy has not yet been proven, and it is not impossible that prolongation of the pregnancy in a potential hostile environment could harm the fetus. Here we reflect on the use of tocolysis, focusing on maintenance and repeated tocolysis, and compare international guidelines and practices to available evidence. Finally, We propose strategies to improve the evaluation and use of tocolytics, with potential implications for future research.

Place, publisher, year, edition, pages
2017. Vol. 41, no 8, p. 468-476
Keywords [en]
Preterm labor, Preterm birth, Tocolysis, Maintenance tocolysis, Repeated tocolysis, I-SPY
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-347725DOI: 10.1053/j.semperi.2017.08.005ISI: 000418315700005PubMedID: 28943054OAI: oai:DiVA.org:uu-347725DiVA, id: diva2:1196998
Available from: 2018-04-11 Created: 2018-04-11 Last updated: 2018-04-11Bibliographically approved

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Bergman, Lina

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