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Effects of androgens on the leptin system in immature male Atlantic salmon parr
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology. CSIC, IATS, Torre Sal S-N, Ribera De Cabanes 12595, Castellon, Spain..
Univ Gothenburg, Dept Biol & Environm Sci, SE-40530 Gothenburg, Sweden..
Univ Stockholm, Dept Zool, S-10691 Stockholm, Sweden..
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2018 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 257, p. 122-129Article in journal (Refereed) Published
Abstract [en]

Leptin modulates all levels of the reproductive endocrine axis in mammals, and in turn, both leptin and the leptin receptor are regulated by sex steroids. The aim of this study was to investigate if sex steroids regulate the leptin system also in fish. Immature one-year old male Atlantic salmon parr were implanted with Silclear capsules that were either empty or filled with 11-ketoandrostenedione (11 KA) or testosterone (T) and the effects of 35-days treatment were investigated on measures of maturation, gene expression of leptin (lepa1, lepa2), leptin receptor (lepra1) and circulating plasma leptin. Both 11-KA and T stimulated the reproductive axis by increasing testes weight and up-regulated pituitary lh-beta mRNA levels and for T also fsh-beta. T up-regulated transcription levels of lepa1 and lepra1 in the pituitary, while 11-KA had no effect. Leptin receptor expression in the testis was unaltered by either androgen. T up-regulated lepa1 mRNA levels significantly also in the liver, but had no effect on lepa2, and 11 KA did not affect hepatic gene expression of either lepa1 or lepa2. Plasma leptin levels did not differ significantly between treatments. The results indicate that androgens regulate gene expression of leptin and the leptin receptor in different tissues in fish and that the effects of leptin might be tissue specific considering plasma levels remained unaltered. Overall, the results suggest a role for leptin in fish reproduction, where sex steroids are able to regulate components of the leptin system differentially in liver and important tissues of the reproductive axis.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2018. Vol. 257, p. 122-129
Keywords [en]
Leptin, Leptin receptor, Testosterone, 11-ketotestosterone, Reproduction, Brain-pituitary-gonad axis, Liver, Teleost
National Category
Zoology
Identifiers
URN: urn:nbn:se:uu:diva-348390DOI: 10.1016/j.ygcen.2017.08.014ISI: 000424858400013PubMedID: 28830748OAI: oai:DiVA.org:uu-348390DiVA, id: diva2:1197909
Conference
8th International Symposium on Fish Endocrinology, JUN 28-JUL 02, 2016, Gothenburg, SWEDEN
Funder
Swedish Research Council FormasAvailable from: 2018-04-16 Created: 2018-04-16 Last updated: 2018-04-16Bibliographically approved

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Trombley, SusanneSchmitz, Monika

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