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The brain-gut axis of fish: Rainbow trout with low and high cortisol response show innate differences in intestinal integrity and brain gene expression
Univ Gothenburg, Dept Biol & Environm Sci, POB 463, SE-40531 Gothenburg, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology.ORCID iD: 0000-0003-4252-3144
Univ Gothenburg, Dept Biol & Environm Sci, POB 463, SE-40531 Gothenburg, Sweden..
2018 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 257, p. 235-245Article in journal (Refereed) Published
Abstract [en]

In fish, the stress hormone cortisol is released through the action of the hypothalamic pituitary interrenal axis (HPI-axis). The reactivity of this axis differs between individuals and previous studies have linked this to different behavioural characteristics and stress coping styles. In the current study, low and high responding (LR and HR) rainbow trout in terms of cortisol release during stress were identified, using a repeated confinements stress test. The expression of stress related genes in the forebrain and the integrity of the stress sensitive primary barrier of the intestine was examined. The HR trout displayed higher expression levels of mineralocorticoid and serotonergic receptors and serotonergic re-uptake pumps in the telencephalon during both basal and stressed conditions. This confirms that HPI-axis reactivity is linked also to other neuronal behavioural modulators, as both the serotonergic and the corticoid system in the telencephalon are involved in behavioural reactivity and cognitive processes. Involvement of the HPI-axis in the brain-gut-axis was also found. LR trout displayed a lower integrity in the primary barrier of the intestine during basal conditions compared to the HR trout. However, following stress exposure, LR trout showed an unexpected increase in intestinal integrity whereas the HR trout instead suffered a reduction. This could make the LR individuals more susceptible to pathogens during basal conditions where instead HR individuals would be more vulnerable during stressed conditions. We hypothesize that these barrier differences are caused by regulation/effects on tight junction proteins possibly controlled by secondary effects of cortisol on the intestinal immune barrier or differences in parasympathetic reactivity.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2018. Vol. 257, p. 235-245
Keywords [en]
Corticoid receptors, HPI-axis reactivity, Intestinal barrier function, Stress coping styles, Serotonin, Telencephalon
National Category
Zoology
Identifiers
URN: urn:nbn:se:uu:diva-348392DOI: 10.1016/j.ygcen.2017.09.020ISI: 000424858400026PubMedID: 28947388OAI: oai:DiVA.org:uu-348392DiVA, id: diva2:1197923
Conference
8th International Symposium on Fish Endocrinology, JUN 28-JUL 02, 2016, Gothenburg, SWEDEN
Funder
Helge Ax:son Johnsons stiftelse Swedish Research Council Formas, 229- 2009-1495, 223-2011-1073Available from: 2018-04-16 Created: 2018-04-16 Last updated: 2018-04-16Bibliographically approved

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Thörnqvist, Per-OveWinberg, Svante

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