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The relationship between changes in inflammatory markers and asthma outcomes over one year of optimized controller treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2018 (English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Introduction: There is lack of knowledge which inflammatory markers that can be related to asthma outcomes and how they correlate with asthma outcomes.

Aim: The primary aim was to analyse the relationship between changes in inflammatory markers and asthma outcomes, between changes in inflammatory markers and asthma medication use, and between asthma medication use and asthma outcomes over one year of optimized controller treatment.

Materials and methods: 159 asthmatics were analysed. Inhaled corticosteroids (ICS) and leukotriene receptor antagonists (LTRA) were the included treatments. The inflammatory markers analysed were 92 cytokines, fractional exhaled nitric oxide (FeNO), immunoglobulin E (IgE), c-reactive protein (CRP), eosinophil cationic protein (ECP) and human neutrophil lipocalin (HNL). The outcomes were measured as a change in Asthma Control Questionnaire (ACQ) score, mini Asthma Quality of Life Questionnaire (mAQLQ) score and forced expiratory volume in one second (FEV1 in litres before bronchodilation).

Results: Asthma medication use correlated with change in few inflammatory markers and FEV1. Change in 35 cytokines correlated with change in ACQ, mAQLQ or FEV1.

Conclusion: Asthma medication probably mainly affect cytokines related to FEV1, while very little effect is seen on cytokines related to ACQ and mAQLQ.  The majority of change in inflammatory markers is related to something else than asthma medication, probably something related to mental health.

Place, publisher, year, edition, pages
2018. , p. 36
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-348852OAI: oai:DiVA.org:uu-348852DiVA, id: diva2:1198607
Subject / course
Pharmacotherapy
Educational program
Master of Science Programme in Pharmacy
Supervisors
Examiners
Available from: 2018-04-18 Created: 2018-04-18 Last updated: 2018-04-18Bibliographically approved

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