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Resistance testing of clindamycin and erythromycin in Streptococcus pyogenes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
2016 (English)Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Background: Group A Streptococcus (GAS) is a known pathogen that cause over 600 million infections per year worldwide. GAS is generally treated with penicillin, but in some cases clindamycin or erythromycin is used. An increase in the resistance to these antibiotics has been observed. So far three phenotypes has been identified, M-, cMLSB-, and iMLSB.Aim: To investigate the resistance of GAS, strains isolated in the county of VästernorrlandSweden.Materials and methods: The resistance of 124 isolates of GAS was examined using the disk diffusion method and E- test.Results: The present study showed that 3 % of the isolates were resistant to clindamycin and 4 % were resistant to erythromycin. iMLSB-phenotype was predominant (80 %), followed by M-phenotype (20 %). No isolate of the cMLSB-phenotype was found (0 %).Conclusion: The incidence of resistance to clindamycin and erythromycin did not exceed 5%, therefore no new procedures for routine susceptibility testing of GAS introduced under thePublic Health Authority recommendations in clinical microbiology in Västernorrland.

Place, publisher, year, edition, pages
2016.
Keywords [en]
Group A Streptococcus, antibiotic resistance, phenotypes, MLSB-resistance, macrolides.
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:uu:diva-349015OAI: oai:DiVA.org:uu-349015DiVA, id: diva2:1199235
Educational program
Biomedical Laboratory Science Programme; Biomedical Laboratory Science Programme
Examiners
Available from: 2018-04-20 Created: 2018-04-19 Last updated: 2018-04-20Bibliographically approved

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