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Evaluating the impact of pneumococcal vaccination in a South East Asian setting
2017 (English)Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Background: Streptococcus pneumoniae is a bacterium causing infection resulting in children mortality and morbidity worldwide. South East Asia holds the most prevalent geographic area for Invasive pneumococcal disease where the burden of IPD is significant in children less than 5 years. In a representative country of South East Asia that has recently introduced pneumococcal conjugate vaccine (PCV13) in 2013 with support from GAVI, IgG antibody titers were measured to evaluate the impact of the vaccine.Aim: To measure serotype-specific IgG levels to serotypes 1 and 5 in serum from infants in a South East Asian country.Methods: Serum from 302 participants aged 0-5 years were analyzed for serotype 1 and 5 specific IgG using the WHO recommended ELISA.Results: Pneumococcus serotype 1 and 5 IgG was detected in the samples where around 50 % of 302 participants had detectable IgG response for both serotypes above 0.35μg/ml (protective cut-off). A higher proportion of infants had IgG antibodies against serotype 5 (n=230) compared to serotype 1 (n=144) above 0.35μg/ml.Conclusion: Analysis of the samples showed varied results in response to PCV13 immunization. Results above 0.35μg/ml were determined positive, and hence were protected against IPD. The vaccine coverage is estimated to be on the increase as many children showed protective IgG responses to serotypes included in the PCV13.

Place, publisher, year, edition, pages
2017.
Keywords [en]
Streptococcus pneumoniae; Pneumococcal conjugated vaccine; South East Asia; Antibody response; IPD
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:uu:diva-349098OAI: oai:DiVA.org:uu-349098DiVA, id: diva2:1199432
External cooperation
Murdoch Children’s Research Institute, Melbourne
Educational program
Biomedical Laboratory Science Programme; Biomedical Laboratory Science Programme
Examiners
Available from: 2018-04-20 Created: 2018-04-20 Last updated: 2018-04-20Bibliographically approved

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