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Molecular expression of receptive stage endometriumin healthy women and women with endometriosis
2017 (English)Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Endometriosis affects about 10-15% of women in their reproductive age, which increases the risk for infertility. The molecular expression profile of receptive endometrium of women with endometriosis may differ from that of receptive endometrium of healthy women. Thus, the objective of this study was to examine the molecular expression in endometrium of women with endometriosis and compare it with the endometrium from healthy women collected during receptive phase.Endometrium was collected during receptive phase from women with endometriosis (n=4) and from healthy women with proven fertility (n=8). Paraformaldehyde fixed and paraffin embedded tissues were sectioned and the differential protein expression of SOX17, ezrin, WT1 and SLPI were studied by use of immunohistochemistry, and analysed under light microscopy for staining intensity and area. Mann-Whitney U-test was performed to find differences in protein staining.We found that protein expression of SOX17 was confined to endometrial glands. The expression of ezrin present in glands was significantly higher in endometrium from women with endometriosis (p<0.01). There were no differences between the two groups in the expression of SOX17 or WT1. We could not find any detectable levels of SLP1 in the endometrial sections. Thus, we conclude that the endometrium of women with endometriosis have differential expression of ezrin.

Place, publisher, year, edition, pages
2017.
Keywords [en]
Immunohistochemikal staining, microarray, ezrin, WT1, SOX17. SLPI.
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:uu:diva-349204OAI: oai:DiVA.org:uu-349204DiVA, id: diva2:1199914
Educational program
Biomedical Laboratory Science Programme; Biomedical Laboratory Science Programme
Examiners
Available from: 2018-04-23 Created: 2018-04-23 Last updated: 2018-04-23Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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  • nn-NO
  • nn-NB
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Output format
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