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STANDARDIZATION OF PATHOGEN REDUCED POOLED SERUM FOR PRODUCTION OF EYE DROPS FOR PATIENTS WITH GRAFT-VERSUS-HOST-DISEASE
2017 (English)Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

A large proportion of the patients who have gone through a stem cell transplantation is affected by a condition called Graft-Versus-Host-Disease, a disease which means that the transplanted immune system attacks the patient’s own cells. To treat the ocular symptoms that may occur with Graft-Versus-Host-Disease, eyedrops has been produced from allogenic serum. The serum contains a lot of the components that patients with Graft-Versus-Host-Disease are missing, such as vitamins, growth factors and fibronectin. The purpose of the study is to standardize and evaluate a method for manufacturing serum eye drops made from pooled pathogen reduced serum. The serum that has been used for the eye drops comes from 12 donors and the serum has later been pooled. The pooled serum has been pathogen reduced and transferred to eye drop containers. Tests have been done to make sure that no bacterial contamination has occurred, to measure the concentration of growth factors and also for quality controls. The results indicated no sign of bacterial contamination but enough high levels of growth factors and a good quality control with no sign of unwanted blood cells. The results therefore determined that the manufacturing of serum eye drops is successful and that they after further studies should be given to patients to mitigate the ocular symptoms of Graft-Versus-Host-Disease.

Place, publisher, year, edition, pages
2017.
Keywords [en]
Stem cell transplantation, Blood component, Dry eye, TGF-β, Ocular
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:uu:diva-349209OAI: oai:DiVA.org:uu-349209DiVA, id: diva2:1199925
Educational program
Biomedical Laboratory Science Programme; Biomedical Laboratory Science Programme
Examiners
Available from: 2018-04-23 Created: 2018-04-23 Last updated: 2018-04-23Bibliographically approved

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