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Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health).
Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.ORCID iD: 0000-0001-8036-168x
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2018 (English)In: PLoS Medicine, ISSN 1549-1277, E-ISSN 1549-1676, Vol. 13, no 2, article id e0192514Article in journal (Refereed) Published
Abstract [en]

Background Preeclampsia is associated with low birth weight, both because of increased risks of preterm and of small-for-gestational-age (SGA) births. Low birth weight is associated with accelerated childhood height gain and cardiovascular diseases later in life. The aim was to investigate if prenatal exposure to preeclampsia is associated with accelerated childhood height gain, also after adjustments for SGA-status and gestational age at birth. Methods In a cohort of children prenatally exposed to preeclampsia (n = 865) or unexposed (n = 22,898) we estimated height gain between birth and five years of age. The mean difference in height gain between exposed and unexposed children was calculated and adjustments were done with linear regression models. Results Children exposed to preeclampsia were on average born shorter than unexposed. Exposed children grew on average two cm more than unexposed from birth to five years of age. After adjustments for maternal characteristics including socioeconomic factors, height, body mass index (BMI) and diabetes, as well as for parents smoking habits, infant's breastfeeding and childhood obesity, the difference was 1.6 cm (95% CI 1.3-1.9 cm). Further adjustment for SGA birth only slightly attenuated this estimate, but adjustment for gestational age at birth decreased the estimate to 0.5 cm (95% CI 0.1-0.7 cm). Conclusion Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood. The association seemed independent on SGA-status, but partly related to shorter gestational age at birth.

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PUBLIC LIBRARY SCIENCE , 2018. Vol. 13, no 2, article id e0192514
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Pediatrics
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URN: urn:nbn:se:uu:diva-348920DOI: 10.1371/journal.pone.0192514ISI: 000425083400026OAI: oai:DiVA.org:uu-348920DiVA, id: diva2:1201440
Funder
Swedish Research Council, 2014-3561
Available from: 2018-04-25 Created: 2018-04-25 Last updated: 2018-04-25Bibliographically approved

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Lundgren, MariaEkholm Selling, KatarinaHögberg, UlfWikström, Anna-Karin

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Gunnarsdottir, JohannaLundgren, MariaEkholm Selling, KatarinaHögberg, UlfWikström, Anna-Karin
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Research group (Dept. of women´s and children´s health)Department of Women's and Children's HealthObstetrics and Reproductive Health ResearchClinical Obstetrics
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