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A molecular atlas of cell types and zonation in the brain vasculature
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Karolinska Inst, AstraZeneca Integrated Cardio Metab Ctr KI AZ ICM, Blickagangen 6, SE-14157 Huddinge, Sweden..
Tianjin Med Univ, Key Lab Postneuroinjury Neurorepair & Regenerat C, Dept Neurosurg,Gen Hosp, Tianjin Neurol Inst,Minist Educ & Tianjin City, Tianjin 300052, Peoples R China..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.ORCID iD: 0000-0003-0700-4381
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2018 (English)In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 554, no 7693, p. 475-480Article in journal (Refereed) Published
Abstract [en]

Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal unexpected cell type differences: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells. We also provide insight into pericyte organotypicity and define a population of perivascular fibroblast-like cells that are present on all vessel types except capillaries. Our work illustrates the power of single-cell transcriptomics to decode the higher organizational principles of a tissue and may provide the initial chapter in a molecular encyclopaedia of the mammalian vasculature.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 554, no 7693, p. 475-480
National Category
Cell and Molecular Biology
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URN: urn:nbn:se:uu:diva-349342DOI: 10.1038/nature25739ISI: 000425597400036PubMedID: 29443965OAI: oai:DiVA.org:uu-349342DiVA, id: diva2:1201789
Funder
AstraZenecaSwedish Research Council, 2015-00550, K2014-64X-20097-09-5EU, European Research Council, AdG294556Swedish Cancer Society, 150735, CAN 2016/271Knut and Alice Wallenberg Foundation, 2015.0030The Swedish Brain Foundation
Available from: 2018-04-26 Created: 2018-04-26 Last updated: 2018-05-18Bibliographically approved

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Vanlandewijck, MichaelMäe, Maarja AndaloussiAndrae, JohannaAndo, KojiNahar, KhayrunLaviña, BàrbaraGouveia, Maria Leonor SeguardoBetsholtz, Christer

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Vanlandewijck, MichaelMäe, Maarja AndaloussiAndrae, JohannaAndo, KojiNahar, KhayrunLaviña, BàrbaraGouveia, Maria Leonor SeguardoBetsholtz, Christer
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Vascular BiologyDepartment of Immunology, Genetics and Pathology
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