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Novel activities of safe-in-human broad-spectrum antiviral agents.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology.ORCID iD: 0000-0001-9684-7887
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2018 (English)In: Antiviral Research, ISSN 0166-3542, E-ISSN 1872-9096, article id S0166-3542(18)30098-6Article in journal (Refereed) Epub ahead of print
Abstract [en]

According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases.

Place, publisher, year, edition, pages
2018. article id S0166-3542(18)30098-6
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Microbiology in the medical area
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URN: urn:nbn:se:uu:diva-350000DOI: 10.1016/j.antiviral.2018.04.016PubMedID: 29698664OAI: oai:DiVA.org:uu-350000DiVA, id: diva2:1203158
Available from: 2018-05-02 Created: 2018-05-02 Last updated: 2018-05-07

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Bergqvist, AndersBondeson, KåreÖhrmalm, Christina

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