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Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Recipharm OT Chem AB, Virdings Alle 16, S-75450 Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.ORCID iD: 0000-0002-4597-041x
2018 (English)In: Analytical Methods, ISSN 1759-9660, E-ISSN 1759-9679, Vol. 10, no 9, p. 938-941Article in journal (Refereed) Published
Abstract [en]

In this study, the effect of mobile phase composition for size exclusion chromatography (SEC) on antibody drug conjugate (ADC) aggregate analysis was investigated. The use of organic components as well as high ionic strength during aggregate analysis was demonstrated to be advantageous.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2018. Vol. 10, no 9, p. 938-941
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-350281DOI: 10.1039/c7ay02696jISI: 000426696100001OAI: oai:DiVA.org:uu-350281DiVA, id: diva2:1204930
Funder
Swedish Research Council, SRC 2015-4870Swedish Foundation for Strategic Research , ID14-0081
Available from: 2018-05-09 Created: 2018-05-09 Last updated: 2018-05-09Bibliographically approved

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Källsten, MalinBergquist, Jonas

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