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The controversial role of mast cells in fibrosis
Univ Leicester, Inst Lung Hlth, Dept Infect Immun & Inflammat, Leicester, Leics, England..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden..ORCID iD: 0000-0002-6779-391x
2018 (English)In: Immunological Reviews, ISSN 0105-2896, E-ISSN 1600-065X, Vol. 282, no 1, p. 198-231Article, review/survey (Refereed) Published
Abstract [en]

Fibrosis is a medical condition characterized by an excessive deposition of extracellular matrix compounds such as collagen in tissues. Fibrotic lesions are present in many diseases and can affect all organs. The excessive extracellular matrix accumulation in these conditions can often have serious consequences and in many cases be life-threatening. A typical event seen in many fibrotic conditions is a profound accumulation of mast cells (MCs), suggesting that these cells can contribute to the pathology. Indeed, there is now substantialv evidence pointing to an important role of MCs in fibrotic disease. However, investigations from various clinical settings and different animal models have arrived at partly contradictory conclusions as to how MCs affect fibrosis, with many studies suggesting a detrimental role of MCs whereas others suggest that MCs can be protective. Here, we review the current knowledge of how MCs can affect fibrosis.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 282, no 1, p. 198-231
Keywords [en]
fibrosis, heart, kidney, liver, lung, mast cell, skin
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-350661DOI: 10.1111/imr.12626ISI: 000424876400013PubMedID: 29431218OAI: oai:DiVA.org:uu-350661DiVA, id: diva2:1205920
Funder
Swedish Heart Lung FoundationSwedish Research CouncilTorsten Söderbergs stiftelseSwedish Cancer SocietyKnut and Alice Wallenberg FoundationAvailable from: 2018-05-15 Created: 2018-05-15 Last updated: 2018-06-04Bibliographically approved

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Pejler, Gunnar

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