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Vestibular Morphology in the German Waltzing Guinea Pig
Karonlinska Institute.
Karonlinska Institute.
Karolinska Institute.ORCID iD: 0000-0002-4717-1558
Karolinska Institute.
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2010 (English)In: Journal of Otolaryngology - Head & Neck Surgery, ISSN 1802-3908, E-ISSN 1916-0216, no 2, p. 115-121Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: 

The German waltzing guinea pig is a special strain of animal with a recessively inherited inner ear defect, resulting in deafness and a severe vestibular dysfunction. The hearing loss in the cochlea of the German strain is a result of a collapse of the Reissner membrane and the absence of scala media. The vestibular organ has not yet been described.

MATERIALS AND METHODS: 

German waltzing guinea pigs (homozygote and heterozygote) of different ages ranging from embryologic age 25 days to adulthood were investigated. The living animals were tested with four different vestibular tests, and the fetuses were controlled according to breeding. The morphology of the vestibular parts (ampulla, saccule, and utricle) was observed by using the light and transmission electron microscopy.

RESULTS: 

Collapse of the membranous labyrinth was found already at embryologic age 50 days and progressed over time. Vestibulardysfunction was noted already from birth.

CONCLUSIONS: 

Vestibular atelectasis has been shown to have the same morphology as the reported vestibular dysfunction in the German waltzing guinea pig. Owing to this similarity, this animal can be a good model for vestibular research.

Place, publisher, year, edition, pages
2010. no 2, p. 115-121
National Category
Medical and Health Sciences Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-350715DOI: 10.2310/7070.2009.090108OAI: oai:DiVA.org:uu-350715DiVA, id: diva2:1205986
Available from: 2018-05-15 Created: 2018-05-15 Last updated: 2018-05-15

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