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Assessment of Impact of HLA Type on Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia
Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH, USA.
Med Coll Wisconsin, Ctr Int Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI, USA.
Med Coll Wisconsin, Ctr Int Blood & Marrow Transplantat, Milwaukee, WI, USA; Med Coll Wisconsin, Dept Med, Milwaukee, WI, USA.
King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
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2018 (English)In: Biology of blood and marrow transplantation, ISSN 1083-8791, E-ISSN 1523-6536, Vol. 24, no 3, p. 581-586Article in journal (Refereed) Published
Abstract [en]

Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy with many highly effective therapies. Chemorefractory disease, often characterized by deletion of chromosome 17p, has historically been associated with very poor outcomes, leading to the application of allogeneic hematopoietic stem cell transplantation (allo-HCT) for medically fit patients. Although the use of allo-HCT has declined since the introduction of novel targeted therapy for the treatment of CLL, there remains significant interest in understanding factors that may influence the efficacy of allo-HCT, the only known curative treatment for CLL. The potential benefit of transplantation is most likely due to the presence of alloreactive donor T cells that mediate the graft-versus-leukemia (GVL) effect. The recognition of potentially tumor-specific antigens in the context of class I and II major histocompatibility complex on malignant B lymphocytes by donor T cells may be influenced by subtle differences in the highly polymorphic HLA locus. Given previous reports of specific HLA alleles impacting the incidence of CLL and the clinical outcomes of allo-HCT for CLL, we sought to study the overall survival and progression-free survival of a large cohort of patients with CLL who underwent allo-HCT from fully HLA-matched related and unrelated donors at Center for International Blood and Marrow Transplant Research transplantation centers. We found no statistically significant association of allo-HCT outcomes in CLL based on previously reported HLA combinations. Additional study is needed to further define the immunologic features that portend a more favorable GVL effect after allo-HCT for CLL.

Place, publisher, year, edition, pages
2018. Vol. 24, no 3, p. 581-586
Keywords [en]
CLL, HLA, Allogeneic transplantation
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-351084DOI: 10.1016/j.bbmt.2017.10.015ISI: 000427663000023PubMedID: 29032274OAI: oai:DiVA.org:uu-351084DiVA, id: diva2:1207113
Funder
NIH (National Institute of Health), U24 CA076518Available from: 2018-05-18 Created: 2018-05-18 Last updated: 2018-05-18Bibliographically approved

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Olsson, Richard F.

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Centrum för klinisk forskning i Sörmland (CKFD)
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