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Same-day imaging using small proteins: Clinical experience and translational prospects in oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Affibody AB, Solna, Sweden.
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2018 (English)In: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667, Vol. 59, no 6, p. 885-891Article in journal (Refereed) Published
Abstract [en]

Imaging of expression of therapeutic targets may enable patients' stratification for targeted treatments. The use of small radiolabeled probes based on the heavy-chain variable region of heavy-chain-only immunoglobulins or non-immunoglobulin scaffolds permits rapid localization of radiotracers in tumors and rapid clearance from normal tissues. This makes high-contrast imaging possible on the day of injection. This mini-review focuses on small proteins for radionuclide-based imaging that would allow same-day imaging, with the emphasis on clinical applications and promising preclinical developments within the field of oncology.

Place, publisher, year, edition, pages
2018. Vol. 59, no 6, p. 885-891
Keywords [en]
Animal Imaging, Molecular Imaging, Oncology: Breast, affibody, nanobody, radionuclide molecular imaging, scaffold proteins
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-351165DOI: 10.2967/jnumed.117.199901ISI: 000435102600013PubMedID: 29545374OAI: oai:DiVA.org:uu-351165DiVA, id: diva2:1208940
Funder
Swedish Cancer SocietySwedish Research Council
Note

De 2 sista författarna delar sistaförfattarskapet.

Available from: 2018-05-21 Created: 2018-05-21 Last updated: 2018-08-24Bibliographically approved

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Frejd, Fredrik Y.Sörensen, JensOrlova, AnnaTolmachev, Vladimir

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