uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Studies of indirect and direct effects of hypervitaminosis A on rat bone by comparing free access to food and pair-feeding.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.ORCID iD: 0000-0003-2791-688X
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.ORCID iD: 0000-0002-8949-3555
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
2018 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, no 2, p. 82-85Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The most prominent features of hypervitaminosis A in rats are spontaneous fractures and anorexia. Since caloric restriction induces alterations in bone, some effects could be secondary to loss of appetite. To clarify the mechanisms behind vitamin A-induced bone fragility it is necessary to distinguish between direct and indirect effects.

MATERIALS AND METHODS: In this study we compared rats fed high doses of vitamin A both with pair-fed controls, which were fed the same amount of chow as that consumed by the vitamin A group to keep food intake the same, and to controls with free access to food.

RESULTS: In contrast to the pair-fed animals, rats in the free access group fed high doses of vitamin A for 7 days had 13% lower food intake, 15% lower body weight, and 2.7% shorter femurs compared with controls. In addition, serum biomarkers of bone turnover were reduced. Peripheral quantitative computed tomography of the femurs showed that the bone mineral content, cross sectional area, and periosteal circumference were similarly reduced in the pair-fed and free access groups. However, bone mineral density (BMD) and cortical parameters were only significantly decreased in the free access group.

CONCLUSIONS: Our data indicate that the major direct short-term effect of high doses of vitamin A on rat bone is a reduced bone diameter, whereas the effects on bone length, serum biomarkers of bone turnover, BMD, and bone cortex appear to be mainly indirect, caused by a systemic toxicity with loss of appetite, reduced food intake, and general effects on growth.

Place, publisher, year, edition, pages
2018. Vol. 123, no 2, p. 82-85
Keywords [en]
Bone, bone turnover serum biomarkers, pQCT, pair-fed, rat, vitamin A
National Category
Nutrition and Dietetics General Practice
Identifiers
URN: urn:nbn:se:uu:diva-351381DOI: 10.1080/03009734.2018.1448020ISI: 000438159000002PubMedID: 29697007OAI: oai:DiVA.org:uu-351381DiVA, id: diva2:1209863
Available from: 2018-05-24 Created: 2018-05-24 Last updated: 2018-09-14Bibliographically approved

Open Access in DiVA

fulltext(858 kB)4 downloads
File information
File name FULLTEXT01.pdfFile size 858 kBChecksum SHA-512
4d600bcce4a2ed23b77baff698ee52a738dbaca12618c86e0cad3c1964b1949b818c1a5fe324e7b9e48163dbf851b03bcb4664486f87b1bf5497be693f22054f
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Lind, ThomasLind, P. MonicaHu, LijuanMelhus, Håkan

Search in DiVA

By author/editor
Lind, ThomasLind, P. MonicaHu, LijuanMelhus, Håkan
By organisation
Clinical pharmacogenomics and osteoporosisOccupational and Environmental Medicine
In the same journal
Upsala Journal of Medical Sciences
Nutrition and DieteticsGeneral Practice

Search outside of DiVA

GoogleGoogle Scholar
Total: 4 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 21 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf