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ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
Swedish Univ Agr Sci, Dept Clin Sci, SE-75007 Uppsala, Sweden..
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Autoimmunity. Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Stockholm, Sweden..ORCID iD: 0000-0002-6163-9540
KTH Royal Inst Technol, Sch Biotechnol, Affin Prote, SciLifeLab, SE-17121 Solna, Sweden..
Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, CMM, L8 01, SE-17176 Stockholm, Sweden..
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 4852Article in journal (Refereed) Published
Abstract [en]

Dogs can spontaneously develop complex systemic autoimmune disorders, with similarities to human autoimmune disease. Autoantibodies directed at self-antigens are a key feature of these autoimmune diseases. Here we report the identification of interleukin enhancer-binding factors 2 and 3 (ILF2 and ILF3) as autoantigens in canine immune-mediated rheumatic disease. The ILF2 autoantibodies were discovered in a small, selected canine cohort through the use of human protein arrays; a method not previously described in dogs. Subsequently, ILF3 autoantibodies were also identified in the same cohort. The results were validated with an independent method in a larger cohort of dogs. ILF2 and ILF3 autoantibodies were found exclusively, and at a high frequency, in dogs that showed a speckled pattern of antinuclear antibodies on immunofluorescence. ILF2 and ILF3 autoantibodies were also found at low frequency in human patients with SLE and Sjogren's syndrome. These autoantibodies have the potential to be used as diagnostic biomarkers for canine, and possibly also human, autoimmune disease.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 8, article id 4852
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Immunology in the medical area
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URN: urn:nbn:se:uu:diva-351425DOI: 10.1038/s41598-018-23034-wISI: 000427688100045PubMedID: 29556082OAI: oai:DiVA.org:uu-351425DiVA, id: diva2:1212346
Funder
Swedish Research CouncilSwedish Research Council Formas, 2011-1404Novo NordiskRagnar Söderbergs stiftelseSwedish Rheumatism AssociationAvailable from: 2018-06-01 Created: 2018-06-01 Last updated: 2018-06-01Bibliographically approved

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Landegren, NilsLeonard, DagEloranta, Maija-LeenaRönnblom, LarsNordmark, GunnelLindblad-Toh, KerstinKämpe, Olle

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Landegren, NilsLeonard, DagEloranta, Maija-LeenaRönnblom, LarsNordmark, GunnelLindblad-Toh, KerstinKämpe, Olle
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Science for Life Laboratory, SciLifeLabAutoimmunityRheumatologyDepartment of Medical Biochemistry and Microbiology
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