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Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany..
Linkoping Univ, Dept Clin Pathol & Clin Genet, S-58185 Linkoping, Sweden.;Linkoping Univ, Dept Clin & Expt Med, S-58185 Linkoping, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
2018 (English)In: Cold Spring Harbor Perspectives in Medicine, ISSN 0103-3247, E-ISSN 2157-1422, Vol. 8, no 1, article id a024323Article in journal (Refereed) Published
Abstract [en]

More than 30 proteins form amyloid in humans, most of them outside of the brain. Deposition of amyloid in extracerebral tissues is very common and seems inevitable for an aging person. Most deposits are localized, small, and probably without consequence, but in some instances, they are associated with diseases such as type 2 diabetes. Other extracerebral amyloidoses are systemic, with life-threatening effects on the heart, kidneys, and other organs. Here, we review how amyloid may spread through seeding and whether transmission of amyloid diseases may occur between humans. We also discuss whether cross-seeding is important in the development of amyloidosis, focusing specifically on the amyloid proteins AA, transthyretin, and islet amyloid polypeptide (IAPP).

Place, publisher, year, edition, pages
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT , 2018. Vol. 8, no 1, article id a024323
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-351767DOI: 10.1101/cshperspect.a024323ISI: 000429143200001OAI: oai:DiVA.org:uu-351767DiVA, id: diva2:1212882
Funder
Swedish Research CouncilErik, Karin och Gösta Selanders FoundationSwedish Diabetes AssociationGerman Research Foundation (DFG), FA 456/15-1
Available from: 2018-06-04 Created: 2018-06-04 Last updated: 2018-06-04Bibliographically approved

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Westermark, GunillaWestermark, Per

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