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Predicting reactivity threshold in children with anaphylaxis to peanut
Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway;Univ Oslo, Inst Clin Med, Oslo, Norway.
Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway;Univ Oslo, Inst Clin Med, Oslo, Norway.
Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway;Univ Oslo, Inst Clin Med, Oslo, Norway.
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2018 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 48, no 4, p. 415-423Article in journal (Refereed) Published
Abstract [en]

Background: Peanut allergy necessitates dietary restrictions, preferably individualized by determining reactivity threshold through an oral food challenge (OFC). However, risk of systemic reactions often precludes OFC in children with severe peanut allergy.

Objective: We aimed to determine whether clinical and/or immunological characteristics were associated with reactivity threshold in children with anaphylaxis to peanut and secondarily, to investigate whether these characteristics were associated with severity of the allergic reaction during OFC.

Methods: A double-blinded placebo-controlled food challenge (DBPCFC) with peanut was performed in 96 5- to 15-year-old children with a history of severe allergic reactions to peanut and/or sensitization to peanut (skin prick test [SPT] 3 mm or specific immunoglobulin E [s-IgE] 0.35 kUA/L). Investigations preceding the DBPCFC included a structured interview, SPT, lung function measurements, serological immunology assessment (IgE, IgG and IgG(4)), basophil activation test (BAT) and conjunctival allergen provocation test (CAPT). International standards were used to define anaphylaxis and grade the allergic reaction during OFC.

Results: During DBPCFC, all 96 children (median age 9.3, range 5.1-15.2) reacted with anaphylaxis (moderate objective symptoms from at least two organ systems). Basophil activation (CD63(+) basophils 15%), peanut SPT and the ratio of peanut s-IgE/total IgE were significantly associated with reactivity threshold and lowest observed adverse events level (LOAEL) (all P < .04). Basophil activation best predicted very low threshold level (<3 mg of peanut protein), with an optimal cut-off of 75.8% giving a 93.5% negative predictive value. None of the characteristics were significantly associated with the severity of allergic reaction.

Conclusion and Clinical Relevance: In children with anaphylaxis to peanut, basophil activation, peanut SPT and the ratio of peanut s-IgE/total IgE were associated with reactivity threshold and LOAEL, but not with allergy reaction severity.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 48, no 4, p. 415-423
Keywords [en]
anaphylaxis, basophil, double-blinded placebo-controlled food challenge, food allergy, immunoglobulin E, immunologic tests, peanut allergy, threshold levels
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-353107DOI: 10.1111/cea.13078ISI: 000428380900007PubMedID: 29284183OAI: oai:DiVA.org:uu-353107DiVA, id: diva2:1216170
Available from: 2018-06-11 Created: 2018-06-11 Last updated: 2018-06-11Bibliographically approved

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Borres, Magnus P

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