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Relationships between surface coverage ratio and powder mechanics of binary adhesive mixtures for dry powder inhalers
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
AstraZeneca, IMED Biotech Unit, Pharmaceut Sci, Gothenburg, Sweden.
AstraZeneca, Inhalat Product Dev Pharmaceut Technol & Dev, Gothenburg, Sweden.
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2018 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 541, no 1-2, p. 143-156Article in journal (Refereed) Published
Abstract [en]

The aim of this paper was to study relationships between the content of fine particles and the powder mechanics of binary adhesive mixtures and link these relationships to the blend state. Mixtures with increasing amounts of fine particles (increasing surface coverage ratios (SCR)) were prepared using Lactopress SD as carrier and micro particles of lactose as fines (2.7 mu m). Indicators of unsettled bulk density, compressibility and flowability were derived and the blend state was visually examined by imaging. The powder properties studied showed relationships to the SCR characterised by stages. At low SCR, the fine particles predominantly gathered in cavities of the carriers, giving increased bulk density and unchanged or improved flow. Thereafter, increased SCR gave a deposition of particles at the enveloped carrier surface with a gradually more irregular adhesion layer leading to a reduced bulk density and a step-wise reduced flowability. The mechanics of the mixtures at a certain stage were dependent on the structure and the dynamics of the adhesion layer and transitions between the stages were controlled by the evolution of the adhesion layer. It is advisable to use techniques based on different types of flow in order to comprehensively study the mechanics of adhesive mixtures.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2018. Vol. 541, no 1-2, p. 143-156
Keywords [en]
Powder flowability, Adhesive mixture, Ordered mixture, Inhalation, Dry powder inhaler, Powder mechanics
National Category
Materials Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-353103DOI: 10.1016/j.ijpharm.2018.02.017ISI: 000428249100016PubMedID: 29454905OAI: oai:DiVA.org:uu-353103DiVA, id: diva2:1216250
Available from: 2018-06-11 Created: 2018-06-11 Last updated: 2018-06-11Bibliographically approved

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Rudén, JonasFrenning, GöranAlderborn, Göran

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