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Anterior cingulate cortex activity as a candidate biomarker for treatment selection in social anxiety disorder
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
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2018 (English)In: BJPsych Open, Vol. 4, no 3Article in journal (Refereed) Published
Abstract [en]

We aimed to identify biomarkers to guide the decision to add selective serotonin reuptake inhibitors (SSRI) to psychological treatment for social anxiety disorder (SAD). Forty-eight patients with SAD underwent functional magnetic resonance imaging and collection of clinical and demographic variables before treatment with cognitive–behavioural therapy, combined on a double-blind basis with either escitalopram or placebo for 9 weeks. Pre-treatment neural reactivity to aversive faces in the dorsal anterior cingulate cortex (ACC), but not clinical/demographic variables, moderated clinical outcomes. Cross-validated individual-level predictions accurately identified 81% of responders/non-responders. Dorsal ACC reactivity is thus a potential biomarker for SAD treatment selection.Declaration of interestNone.

Place, publisher, year, edition, pages
Cambridge University Press , 2018. Vol. 4, no 3
Keywords [en]
Functional magnetic resonance imaging, anxiety, prediction, selective serotonin reuptake inhibitors, cognitive–behavioural therapy, social phobia
National Category
Psychology
Identifiers
URN: urn:nbn:se:uu:diva-353596DOI: 10.1192/bjo.2018.15OAI: oai:DiVA.org:uu-353596DiVA, id: diva2:1218161
Available from: 2018-06-14 Created: 2018-06-14 Last updated: 2018-06-14

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Publisher's full texthttps://www.cambridge.org/core/article/anterior-cingulate-cortex-activity-as-a-candidate-biomarker-for-treatment-selection-in-social-anxiety-disorder/2EBA9752F316BC27697D755B658729E9

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Frick, AndreasEngman, JonasGingnell, MalinFredrikson, MatsFurmark, Tomas
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