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Extreme prematurity, treated retinopathy, bronchopulmonary dysplasia and cerebral palsy are significant risk factors for ophthalmological abnormalities at 6.5 years of age
Univ Gothenburg, Sahlgrenska Acad, Sect Pediat Ophthalmol, Gothenburg, Sweden.
Lund Univ, Ctr Reprod Epidemiol, Lund, Sweden.
Örebro Univ, Dept Ophthalmol, Örebro, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
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2018 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, no 5, p. 811-821Article in journal (Refereed) Published
Abstract [en]

Aim: This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm.

Methods: We carried out a prospective population‐based study of all children born in Sweden at a gestational age of 22 + 0 to 26 + 6 weeks based on the Extremely Preterm Infants in Sweden Study. The main outcome measures were a combined score of visual impairment, refractive errors and strabismus at 6.5 years of age. Models of univariate and multivariable regression were used to analyse potential prenatal and postnatal predictive factors at different clinically relevant time‐points from one minute after birth to 30 months.

Results: We focused on 399 known extremely preterm survivors and compared them to 300 full‐term controls. Significant antecedents for ophthalmological abnormalities included prematurity per se, retinopathy of prematurity that required treatment, severe bronchopulmonary dysplasia and cerebral palsy. Severe intraventricular haemorrhage was no longer a significant risk factor when we adjusted it for the 30‐month cognitive and neuromotor development outcomes.

Conclusion: This time‐course risk analysis model showed a changing panorama of significant risk factors for ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm.

Place, publisher, year, edition, pages
2018. Vol. 107, no 5, p. 811-821
Keywords [en]
Bronchopulmonary dysplasia, Intraventricular haemorrhage, Ophthalmological outcome, Perinatal risk factors, Retinopathy of prematurity
National Category
Pediatrics Ophthalmology
Identifiers
URN: urn:nbn:se:uu:diva-353365DOI: 10.1111/apa.14206ISI: 000430115100015PubMedID: 29281748OAI: oai:DiVA.org:uu-353365DiVA, id: diva2:1220647
Funder
Swedish Research Council, 2006-3858]Swedish Research Council, 2009-4250]Swedish Society of MedicineAvailable from: 2018-06-19 Created: 2018-06-19 Last updated: 2018-06-19Bibliographically approved

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Holmström, GerdSerenius, Fredrik

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