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The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study
Univ Cape Town, Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Anzio Rd, ZA-7925 Cape Town, South Africa;Univ Cape Town, Inst Neurosci, Cape Town, South Africa.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology. Univ Cape Town, Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Anzio Rd, ZA-7925 Cape Town, South Africa.
Univ Cape Town, Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Anzio Rd, ZA-7925 Cape Town, South Africa;MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa;Univ Cape Town, Inst Neurosci, Cape Town, South Africa.
Univ Cape Town, Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Anzio Rd, ZA-7925 Cape Town, South Africa;Univ Cape Town, Inst Neurosci, Cape Town, South Africa.
2018 (English)In: Drug And Alcohol Dependence, ISSN 0376-8716, E-ISSN 1879-0046, Vol. 185, p. 226-237Article in journal (Refereed) Published
Abstract [en]

Background

Abuse of methamphetamine (MA) is a global health concern. Previous H-1-MRS studies have found that, with methamphetamine abstinence (MAA), there are changes in n-acetyl-aspartate (NAA/Cr), myo-inositol (mI/Cr), choline (Cho/Cr and Cho/NAA), and glutamate with glutamine (Glx) metabolites. Limited studies have investigated the effect of acute MAA, and acute-to-short-term MAA on brain metabolites.

Methods

Adults with chronic MA dependence (n = 31) and healthy controls (n = 22) were recruited. Two-dimensional chemical shift H-1-MRS imaging (TR2000 ms, TE30 ms) slice was performed and included voxels in bilateral anterior-cingulate (ACC), frontal-white-matter (FWM), and dorsolateral-prefrontal-cortices (DLPFC). Control participants were scanned once. The MA group was scanned twice, with acute (1.5 +/- 0.6 weeks, n = 31) and short-term MAA (5.1 +/- 0.8 weeks, n = 22). The change in H-1-MRS metabolites over time (n = 19) was also investigated. Standard H-1-MRS metabolites are reported relative to Cr + PCr.

Results

Acute MAA showed lower n-acetyl-aspartate (NAA) and n-acetyl-aspartate with n-acetyl-aspartyl-glutamate (NAA + NAAG) in left DLPFC, and glycerophosphocholine with phosphocholine (GPC + PCh) in left FWM. Short-term MAA showed lower NAA + NAAG and higher myo-inositol (mI) in right ACC, lower NAA and NAA + NAAG in the left DLPFC, and lower GPC + PCh in left FWM. Over time, MAA showed decreased NAA and NAA + NAAG and increased mI in right ACC, decreased NAA and NAA + NAAG in right FWM, and decreased in mI in left FWM.

Conclusion

In acute MAA, there was damage to the integrity of neuronal tissue, which was enhanced with short-term MAA. From acute to short-term MAA, activation of neuroinflammatory processes are suggested. This is the first H-1-MRS study to report the development of neuroinflammation with loss of neuronal integrity in MAA.

Place, publisher, year, edition, pages
2018. Vol. 185, p. 226-237
Keywords [en]
Methamphetamine abstinence, H-1-MRS, Neuroinflammation, Neuroimaging
National Category
Transport Systems and Logistics
Identifiers
URN: urn:nbn:se:uu:diva-354245DOI: 10.1016/j.drugalcdep.2017.11.029ISI: 000430784100030PubMedID: 29471227OAI: oai:DiVA.org:uu-354245DiVA, id: diva2:1220960
Available from: 2018-06-19 Created: 2018-06-19 Last updated: 2018-06-19Bibliographically approved

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