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Conjugation of cyclodextrin to magnetic Fe3O4 nanoparticles via polydopamine coating for drug delivery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Institute for Advanced Studies in Basic Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Institute for Advanced Studies in Basic Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.ORCID iD: 0000-0002-7356-3002
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.ORCID iD: 0000-0001-9998-0480
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2018 (English)In: Progress in organic coatings, ISSN 0300-9440, E-ISSN 1873-331X, Vol. 114, p. 154-161Article in journal (Refereed) Published
Abstract [en]

Abstract

In this study, a novel magnetic nanocarrier for hydrophobic drugs (β-CD–PDA–MNPs) was fabricated using surface coating of Fe3O4 nanoparticles with polydopamine (PDA) followed by functionalization with 6-thio-β-cyclodextrin (6-thio-β-CD). The obtained magnetic nanoparticles were employed to investigate their interactions with diclofenac (DCF) as a model hydrophobic drug. The resulting β-CD–PDA–MNPs were characterized by various methods including transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and vibrating sample magnetometry (VSM). The newly fabricated magnetic nanocarrier exhibited considerably higher drug loading capacity as compared for its analogue lacking CD ligands. Moreover, the release profile of DCF from β-CD–PDA–MNPs showed a burst release during the initial 8 h followed by the drug sustained release. Facile coating of magnetic nanoparticles with PDA was therefore a robust synthetic procedure for the conversion of the nanoparticles into a drug vehicle.

Place, publisher, year, edition, pages
2018. Vol. 114, p. 154-161
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Other Physics Topics Engineering and Technology
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URN: urn:nbn:se:uu:diva-354511DOI: 10.1016/j.porgcoat.2017.10.007OAI: oai:DiVA.org:uu-354511DiVA, id: diva2:1221584
Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-10-12Bibliographically approved

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Oroujeni, MaryamXia, WeiJönsson, Petra

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Department of Immunology, Genetics and PathologyApplied Materials SciencesDepartment of Physics and Astronomy
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Progress in organic coatings
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