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Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei.
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2016 (English)In: Journal of natural products (Print), ISSN 0163-3864, E-ISSN 1520-6025, Vol. 79, no 9, p. 2181-2187Article in journal (Refereed) Published
Abstract [en]

The phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Pentas parvifolia led to the isolation of three new naphthalenes, parvinaphthols A (1), B (2), and C (3), two known anthraquinones, and five known naphthalene derivatives. Similar investigation of the roots of Pentas bussei afforded a new polycyclic naphthalene, busseihydroquinone E (4), a new 2,2'-binaphthralenyl-1,1'-dione, busseihydroquinone F (5), and five known naphthalenes. All purified metabolites were characterized by NMR and MS data analyses, whereas the absolute configurations of 3 and 4 were determined by single-crystal X-ray diffraction studies. The E-geometry of compound 5 was supported by DFT-based chemical shift calculations. Compounds 2-4 showed marginal cytotoxicity against the MDA-MB-231 human triple-negative breast cancer cell line with IC50 values ranging from 62.3 to 129.6 μM.

Place, publisher, year, edition, pages
2016. Vol. 79, no 9, p. 2181-2187
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Organic Chemistry
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URN: urn:nbn:se:uu:diva-355965DOI: 10.1021/acs.jnatprod.6b00178PubMedID: 27518587OAI: oai:DiVA.org:uu-355965DiVA, id: diva2:1231994
Available from: 2018-07-10 Created: 2018-07-10 Last updated: 2018-07-10

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