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Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.
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2016 (English)In: Diseases (Basel, Switzerland), ISSN 2079-9721, Vol. 4, no 1, article id E3Article in journal (Refereed) Published
Abstract [en]

As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8'-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone (2) and cis-isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3'-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520-82.1 μM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 μg/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 μg/mL). The radical scavenging activity of the isolated constituents (1-5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.

Place, publisher, year, edition, pages
2016. Vol. 4, no 1, article id E3
Keywords [en]
DPPH, Diospyros shimbaensis, Ebenaceae, MDA-MB-231, cytotoxicity, naphthoquinoes, radical scavenging, tetralones
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-355966DOI: 10.3390/diseases4010003PubMedID: 28933383OAI: oai:DiVA.org:uu-355966DiVA, id: diva2:1232003
Available from: 2018-07-10 Created: 2018-07-10 Last updated: 2018-07-10

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