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The challenges of integrating two genomes in one cell
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution.
2018 (English)In: Current Opinion in Microbiology, ISSN 1369-5274, E-ISSN 1879-0364, Vol. 41, p. 89-94Article, review/survey (Refereed) Published
Abstract [en]

Mutualistic bacteria and mitochondria have small genomes that harbor host-essential genes. A major question is why a distinct bacterial or mitochondrial genome is needed to encode these functions. The dual location of genes demand two sets of information processing systems, coordination of gene expression and elaborate transport systems. A simpler solution would be to harbor all genes in a single genome. Functional gene transfers to the host nuclear genome is uncommon in mutualistic bacteria and lost gene functions are rather rescued by co-symbiotic bacteria. Recent findings suggest that the mitochondria! genome is retained to avoid conflicting signals between protein targeting pathways in the cell. However, if the selective pressure for oxygenic respiration is lost, the mitochondrial genome will start to deteriorate and soon be lost.

Place, publisher, year, edition, pages
CURRENT BIOLOGY LTD , 2018. Vol. 41, p. 89-94
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-357190DOI: 10.1016/j.mib.2017.12.003ISI: 000429514300014PubMedID: 29277086OAI: oai:DiVA.org:uu-357190DiVA, id: diva2:1238453
Funder
Swedish Research Council, 349-2007-8732Swedish Research Council, 621-2014-4460Knut and Alice Wallenberg Foundation, 2011.0148Knut and Alice Wallenberg Foundation, 2012.0075Available from: 2018-08-13 Created: 2018-08-13 Last updated: 2018-08-13Bibliographically approved

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Hagström, ErikAndersson, Siv G. E.

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