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Paramagnetic ligand tagging to identify ligand-protein binding sites
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC. (Mate Erdelyi)
2018 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Ligand-protein interactions are pivotal in living organisms. Knowing the binding sites of small-molecule ligands, especially low affinity ones, is an important step for modern drug discovery as it enables the development of high affinity lead compounds. Due to the lack of robust characterization approaches, the determination of weak binding is still cumbersome. We have reported a paramagnetic ligand tagging method by taking advantage of pseudo-contact shifts of protein NMR, which requires the ligand to be linked to a paramagnetic lanthanide complex.1 In this project we have improved the structure of our original paramagnetic tag to increase the accuracy of the NMR-based  structure determination as compared to our previously presented approach.

Place, publisher, year, edition, pages
2018.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-357805OAI: oai:DiVA.org:uu-357805DiVA, id: diva2:1240482
Conference
EMBO Course: Multidimensional NMR in Structural Biology 2018
Funder
Swedish Research CouncilAvailable from: 2018-08-21 Created: 2018-08-21 Last updated: 2018-08-21

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Xiong, Ruisheng

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