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Greater attention should be paid to developing therapies for elderly patients with Hodgkin lymphoma: A population-based study from Sweden
Karolinska Univ Hosp Solna, Dept Med, Div Hematol, Stockholm, Sweden;Karolinska Inst, Stockholm, Sweden.
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden;Karolinska Univ Hosp Solna, Stockholm, Sweden.
Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden;Karolinska Univ Hosp Solna, Stockholm, Sweden.
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2018 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 101, no 1, p. 106-114Article in journal (Refereed) Published
Abstract [en]

Objective: Forty percent of Hodgkin lymphoma (HL) patients are older than 50years at diagnosis, a fact which is not commonly recognized. Older patients do significantly worse than younger patients and are rarely included in clinical trials.

Methods: Using data from Swedish Cancer and Lymphoma Registries, we estimated relative survival ratios (RSRs) for 7997 HL patients (diagnosed 1973-2013; 45% 50years).

Results: The 1-year RSRs (95% confidence interval; CI) for males aged 45-59, 60-69, 70-80, and 81years and over, diagnosed in 2013, were 0.95 (0.91-0.97), 0.88 (0.81-0.92), 0.74 (0.63-0.81), and 0.52 (0.35-0.67), respectively. The corresponding 1-year RSRs for females were 0.97 (0.94-0.98), 0.91 (0.85-0.95), 0.82 (0.73-0.88), and 0.66 (0.50-0.77). No improvements in 1-year of 5-year relative survival from 2000 to 2013 were observed for patients aged 45-59 or 60-69 but there were modest improvements for patients aged 70years and older. Importantly, we saw no changes in the distribution of disease or patient characteristics between 2000 and 2013.

Conclusions: Elderly patients constitute a large group with clearly unmet medical needs. Our findings motivate a more active approach to including elderly patients in clinical trials. Our study provides a baseline for outcome comparison after the broader introduction of targeted drugs.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 101, no 1, p. 106-114
Keywords [en]
elderly, Hodgkin lymphoma, relative survival, temporal trends
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-358265DOI: 10.1111/ejh.13090ISI: 000435935800012PubMedID: 29727497OAI: oai:DiVA.org:uu-358265DiVA, id: diva2:1242257
Funder
Swedish Research CouncilSwedish Cancer SocietyStockholm County CouncilThe Karolinska Institutet's Research FoundationAvailable from: 2018-08-27 Created: 2018-08-27 Last updated: 2018-08-27Bibliographically approved

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