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Involvement of Serotonin in crayfish hematopoiesis
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
2018 (English)In: Developmental and Comparative Immunology, ISSN 0145-305X, E-ISSN 1879-0089, Vol. 86, p. 189-195Article in journal (Refereed) Published
Abstract [en]

Serotonin (5-HT) is a conserved monoamine neurotransmitter that has several physiological functions both in vertebrates and invertebrates. In addition to its well-known function in the central nervous system, 5-HT also participates in peripheral system. However, in crustaceans, the knowledge about peripheral functions of 5-HT is limited. In this study, a role of 5-HT in hematopoiesis in crayfish, Pacifastacus leniusculus, was investigated. The presence of 5-HT in crayfish plasma and the effect of 5-HT injection on hemocyte number were examined. The effects of 5-HT on hematopoietic tissue (HPT) cell proliferation and secretion of the hematopoietic cytokine, astakine 1 (Ast 1) were determined in vitro. The results from this study suggest that 5-HT has no direct effect on HPT cell proliferation, but it participates in crayfish hematopoiesis through stimulating Ast 1 cytokine release from crayfish hemocytes, and thereby affects release of new hemocytes into the circulation.

Place, publisher, year, edition, pages
2018. Vol. 86, p. 189-195
Keywords [en]
Serotonin, Astakine 1, Crayfish, Hemocyte, Hematopoiesis
National Category
Immunology Zoology
Identifiers
URN: urn:nbn:se:uu:diva-358358DOI: 10.1016/j.dci.2018.05.006ISI: 000435060900021PubMedID: 29778989OAI: oai:DiVA.org:uu-358358DiVA, id: diva2:1242763
Available from: 2018-08-29 Created: 2018-08-29 Last updated: 2018-08-29Bibliographically approved

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Noonin, Chadanat

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