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Reduction in White Blood Cell, Neutrophil and Red Blood Cell counts Related to Gender, HLA and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes
Lund Univ, Clin Res Ctr, Skåne Univ Hosp, Dept Clin Sci, Malmö, Sweden. (TEDDY Study Group)
Univ S Florida, Hlth Informat Inst, Dept Pediat, Tampa, FL USA. (TEDDY Study Group)
Uppsala University, Science for Life Laboratory, SciLifeLab. (TEDDY Study Group)
Lund Univ, Clin Res Ctr, Skåne Univ Hosp, Dept Clin Sci, Malmö, Sweden. (TEDDY Study Group)
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2018 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 67, no 11, p. 2329--2336, article id db180355Article in journal (Refereed) Published
Abstract [en]

Islet autoantibodies (IAs) precede the clinical onset of type 1 diabetes (T1D); however, the knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4- to 12-year-old children with increased genetic risk for T1D. This study tested whether CBCs were altered in 4- to 12-year-old children without (n = 376) or with one or several IAs against insulin, GAD65, or IA-2 (n = 72). CBC was analyzed during longitudinal follow-up in 448 Swedish children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A linear mixed-effects model was used to assess potential association between IA and CBC measurements over time. The white blood cell and neutrophil counts were reduced in children with IAs, primarily in boys. In contrast, girls had lower levels of hemoglobin and hematocrit. Positivity for multiple IAs showed the lowest counts in white blood cells and neutrophils in boys and red blood cells, hemoglobin, and hematocrit in girls. These associations were primarily observed in children with the HLA-DR3-DQ2/DR4-DQ8 genotype. We conclude that the reduction in neutrophils and red blood cells in children with multiple IAs and HLA-DR3-DQ2/DR4-DQ8 genotype may signal a sex-dependent islet autoimmunity detected in longitudinal CBCs.

Place, publisher, year, edition, pages
2018. Vol. 67, no 11, p. 2329--2336, article id db180355
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-360047DOI: 10.2337/db18-0355ISI: 000448238400019PubMedID: 30104249OAI: oai:DiVA.org:uu-360047DiVA, id: diva2:1246828
Available from: 2018-09-10 Created: 2018-09-10 Last updated: 2019-01-08Bibliographically approved

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