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Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes
Polish Acad Sci, Nalecz Inst Biocybemet & Biomed Engn, Trojdena 4, PL-02109 Warsaw, Poland.
Polish Acad Sci, Nalecz Inst Biocybemet & Biomed Engn, Trojdena 4, PL-02109 Warsaw, Poland;Lawson Hlth Res Inst, Imaging Div, London, ON N61 4172, Canada;Western Univ, Dept Med Biophys, London, ON N6A 51, Canada.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Polish Acad Sci, Nalecz Inst Biocybemet & Biomed Engn, Trojdena 4, PL-02109 Warsaw, Poland.
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2018 (English)In: Biomedical Optics Express, ISSN 2156-7085, E-ISSN 2156-7085, Vol. 9, no 7, p. 2974-2993Article in journal (Refereed) Published
Abstract [en]

An optical technique based on diffuse reflectance measurement combined with indocyanine green (ICG) bolus tracking is extensively tested as a method for the clinical assessment of brain perfusion at the bedside. We report on multiwavelength time-resolved diffuse reflectance spectroscopy measurements carried out on the head of a healthy adult during the intravenous administration of a bolus of ICG. Intracerebral and extracerebral changes in absorption were estimated from an analysis of changes in statistical moments (total number of photons, mean time of flight and variance) of the distributions of times of flight (DTOF) of photons recorded simultaneously at 16 wavelengths from the range of 650-850 nm using sensitivity factors estimated by diffusion approximation based on a layered model of the studied medium. We validated the proposed method in a series of phantom experiments and in-vivo measurements. The results obtained show that changes in the concentration of the ICG can be assessed as a function of time of the experiment and depth in the tissue. Thus, the separation of changes in ICG concentration appearing in intra-and extracerebral tissues can be estimated from optical data acquired at a single source-detector pair of fibers/fiber bundles positioned on the surface of the head.

Place, publisher, year, edition, pages
OPTICAL SOC AMER , 2018. Vol. 9, no 7, p. 2974-2993
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Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-360194DOI: 10.1364/BOE.9.002974ISI: 000437460600007PubMedID: 29984079OAI: oai:DiVA.org:uu-360194DiVA, id: diva2:1247055
Available from: 2018-09-11 Created: 2018-09-11 Last updated: 2018-09-11Bibliographically approved

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Weigl, Wojciech

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