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Dachsousl-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report
I2MC INSERM UMR 1048, Toulouse, France.
Kings Coll London, Dept Craniofacial Dev & Stem Cell Biol, London, England.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
I2MC INSERM UMR 1048, Toulouse, France.ORCID iD: 0000-0002-5282-3776
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2017 (English)In: Arteriosclerosis, Thrombosis and Vascular Biology, ISSN 1079-5642, E-ISSN 1524-4636, Vol. 37, no 9, p. 1732-1735Article in journal (Refereed) Published
Abstract [en]

Objective-The purpose of this study was to investigate the role of Fat4 and Dachsous 1 signaling in the lymphatic vasculature. Approach and Results-Phenotypic analysis of the lymphatic vasculature was performed in mice lacking functional Fat4 or Dachsousl. The overall architecture of lymphatic vasculature is unaltered, yet both genes are specifically required for lymphatic valve morphogenesis. Valve endothelial cells (Proxl(high) [prospero homeobox protein 1] cells) are disoriented and failed to form proper valve leaflets. Using Lifeact-GFP (green fluorescent protein) mice, we revealed that valve endothelial cells display prominent actin polymerization. Finally, we showed the polarized recruitment of Dachsousl to membrane protrusions and cellular junctions of valve endothelial cells in vivo and in vitro. Conclusions-Our data demonstrate that Fat4 and Dachsousl are critical regulators of valve morphogenesis. This study highlights that valve defects may contribute to lymphedema in Hennekam syndrome caused by Fat4 mutations.

Place, publisher, year, edition, pages
2017. Vol. 37, no 9, p. 1732-1735
Keywords [en]
cell polarity, endothelial cells, intercellular junctions, lymphangiogenesis, lymphedema
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-361068DOI: 10.1161/ATVBAHA.117.309818ISI: 000408197600024PubMedID: 28705793OAI: oai:DiVA.org:uu-361068DiVA, id: diva2:1250051
Funder
Swedish Research CouncilAvailable from: 2018-09-21 Created: 2018-09-21 Last updated: 2018-09-21Bibliographically approved

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Martinez-Corral, InesMäkinen, Taija

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