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Novel Functional Imaging of Neuroendocrine Tumors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
2018 (English)In: Endocrinology and metabolism clinics of North America (Print), ISSN 0889-8529, E-ISSN 1558-4410, Vol. 47, no 3, p. 505-523, article id S0889-8529(18)30515-2Article in journal (Refereed) Published
Abstract [en]

Somatostatin receptor imaging constitutes an integral part in neuroendocrine tumor visualization and should, because of its vastly superior performance, use 68Ga-DOTA-somatostatin analogue-PET/computed tomography rather than scintigraphy; it is particularly valuable for detecting metastases to lymph nodes, bone, peritoneum, and liver, which may be missed by morphologic imaging. 18FDG-PET/computed tomography is better suited for G3 and high-G2 neuroendocrine tumors. 18FDG-PET/computed tomography provides prognostic information. Alternative available PET tracers are 18F-DOPA and 11C-5-hydroxytryptophan. To take full advantage of the technique PET/computed tomography should include diagnostic intravenous contrast-enhanced computed tomography. PET/MRI is currently mainly investigational.

Place, publisher, year, edition, pages
2018. Vol. 47, no 3, p. 505-523, article id S0889-8529(18)30515-2
Keywords [en]
(11)C-5-hydroxy-tryptophan, (18)F-Dopa, (68)Ga-Dota-noc, (18)FDG, (68)Ga-Dota-tate, (68)Ga-Dota-toc
National Category
Medical and Health Sciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-362205DOI: 10.1016/j.ecl.2018.04.003ISI: 000444367100006PubMedID: 30098713OAI: oai:DiVA.org:uu-362205DiVA, id: diva2:1252617
Available from: 2018-10-02 Created: 2018-10-02 Last updated: 2018-11-20Bibliographically approved

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Sundin, Anders

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